Pinoresinol Boosts Oral Barrier Integrity in Human Buccal Cells

Posted: September 9, 2025
A study found that pinoresinol, a lignan with antioxidant properties, improves oral epithelial barrier function in human buccal cell monolayers. Pinoresinol treatment reduced permeability, increased electrical resistance, and upregulated tight junction-associated molecules like occludin and claudin-3. This enhancement in barrier integrity suggests pinoresinol may aid in preventing oral diseases linked to barrier dysfunction.

This article summary was generated by AI. To view the full article, click the link here: https://pubmed.ncbi.nlm.nih.gov/40920795/
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